Silvec 1% Cream

✔️ Uses of Silvec 1% Cream

Cuts, Wounds, Severe burns, Post-operative wound dressing

✔️ Side Effects of Silvec 1% Cream

• Application site reactions (burning, irritation, itching and redness)

✔️ How does Silvec 1% Cream work?

Silvec 1% Cream prevents the bacteria from producing folic acid, a nutrient required for bacterial multiplication, and acts upon bacterial cell walls and cell membranes. 

✔️ Some Suggestions while using Silvec 1% Cream

• To soothe a burn, cool it with running water or a cool compress, and remove tight clothing.
• Consider a tetanus shot.
• Avoid harsh products and scratching the area.
• Maintain a healthy lifestyle, manage stress, and stay hydrated.
• Prevent infections by not walking barefoot in public areas.

✔️ Indication of Silver Sulphadiazine 1% Cream.

Silver sulphadiazine 1% cream treats bacterial infections, burns, and wound infections. 

✔️ Pharmacology

The antibacterial action of Silverzine 1% involves several mechanisms. Upon exposure to the drug, structural changes occur in the bacterial cell membrane, leading to distortion, enlargement, and weakening of the cell wall membrane. This process reduces the viability of sensitive bacterial strains. The Silverzine 1% molecule dissociates, and the silver moiety binds to bacterial cells. Once inside the cell wall, the silver moiety attaches to bacterial DNA, preventing bacterial cell proliferation. The ratio of Silverzine 1% to bacterial DNA is believed to be sufficiently high to inhibit bacterial division, while the corresponding ratio to epithelial DNA is low enough to allow epithelial cell regeneration. Additionally, the sulfadiazine moiety contributes to a bacteriostatic action against sensitive organisms. In adults, up to 10% of sulfadiazine may be absorbed, with 60 to 85% of the absorbed amount excreted in the urine. In children with 13% body surface area burns the urinary sulfadiazine concentration was measured at 31.8 mg/L.

✔️ Direction for use:

• Silvec 1% Cream is for external use only.
• Apply the advised amount of cream/ointment with the help of an applicator or a clean cotton ball or swab on the affected areas.
• Wash your hands before and after using Silvec 1% Cream if your hands are not the affected area to prevent the spread of infection.

✔️ Interaction

Caution is advised in patients with G-6-PD deficiency, renal impairment, or prior allergic reactions to sulfonamides. Sulfadiazine may accumulate in those with hepatic or renal dysfunction. Watch for fungal superinfections and consider analgesics before application. Systemic absorption is notable, warranting vigilance for adverse effects.

✔️ Contraindications

Silver sulfadiazine cream is not recommended for individuals with known hypersensitivity to silver sulphonamide, cetyl alcohol, or propylene glycol. Due to the potential risk of kernicterus associated with sulphonamide therapy, it should be avoided in pregnant women at term, premature infants, or infants in the first months of life. Additionally, it is contraindicated in cases of impaired hepatic or renal function, as well as suspected porphyria.

✔️ Precautions & Warnings

• Caution is advised in individuals with significant hepatic or renal impairment, or if porphyria is suspected.
• Patients known to be sensitive to systemic sulphonamides should use the cream cautiously.
• Caution is necessary in individuals with glucose-6-phosphate dehydrogenase deficiency.
• Concurrent use with topical proteolytic enzymes should be approached with caution.
• The application of silver sulfadiazine cream may delay the separation of burn eschar and alter the appearance of burn wounds.
• Regarding lactation, it is not known if the cream is distributed into breast milk, so caution is advised.

✔️ Storage:

Store in a cool and dry place away from direct sunlight. Keep it out of the reach of children and pets.